Tehran retaliates after Iranian leader killed, threatening regional security

Iran on Sunday attempted to exact a heavy price on the United States, Israel, and Washington’s Arab allies over the killing of Iran’s supreme leader.

Hundreds of Iranian missiles and drones rained down on U.S. bases, embassies, Western businesses, airports, hotels, and residential buildings in Gulf countries, Jordan, and Israel. Air-defense systems prevented widespread casualties, but the attacks that succeeded exacted significant damage, including the conflict’s first American casualties.

The Iranian government defended the strikes as legitimate self-defense, claiming the Islamic Republic is targeting U.S. military bases. But the reality on the ground indicates a different strategy, threatening global travel and international trade. The Iranian barrages and subsequent escalation of U.S. and Israeli strikes have also heightened concerns of a broader and more prolonged regional war.

Why We Wrote This

Iran showered the region with missiles and drones this weekend, raising the stakes for the U.S. and Israel, which responded with intensified strikes. The escalation risks destabilizing the Middle East and threatening the global economy.

The retaliatory strikes were seen as revenge for the killing of Iranian leader Ayatollah Ali Khamenei – a spiritual guide for many Iranians as well as Shiite Muslims around the world – and a bid to pressure the Trump administration to stop its punishing campaign.

Instead, the U.S. and Israel intensified their bombing of Iran on Sunday, designed to wipe out the regime’s remaining leadership. President Donald Trump told Fox News that the operation had killed 48 senior Iranian leaders and was “moving along rapidly.”

A plume of smoke caused by an Iranian strike is seen in the background as airliners are seen parked at the closed Dubai International Airport in the United Arab Emirates, March 1, 2026.

Yet, Iranian missile strikes were increasingly able to break through regional missile defenses, killing at least 11 civilians in Israel and three people in the United Arab Emirates.

U.S. Central Command on Sunday reported that three American service members were killed in action and five others had been seriously wounded as of Sunday afternoon. CENTCOM did not indicate where or how the service members were hit.

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