Hollywood is in the middle of a skinny revolution.
Weight-loss jabs like Ozempic and Wegovy are transforming stars of all shapes, with almost every month bringing a ‘suddenly slim’ celebrity debut that sends fans into a frenzy.
Even celebrities not typically known for curves — like Sharon Osbourne, Serena Williams, and Tori Spelling — have dropped hints they turned to medical help to shed pounds.
But it’s the former body-positive stars — Amy Schumer, Lizzo, Meghan Trainor, Kathy Bates, Oprah Winfrey, and more — whose dramatic shrinkdowns are turning heads and raising eyebrows across Hollywood.
These are the same stars who have long championed curves, fuller figures, and body acceptance, making their transformations all the more shocking.
Now, the Daily Mail takes a look at all the body-acceptance icons who have slimmed down thanks to GLP-1s, and how the new skinny is flipping beauty standards in Tinseltown.
Weight-loss jabs like Ozempic and Wegovy are transforming stars of all shapes, with almost every month bringing a ‘suddenly slim’ celebrity debut that sends fans into a frenzy; (Meghan Trainor in October)
It’s the former body-positive stars — Amy Schumer (pictured), Lizzo , Meghan Trainor , Kathy Bates, Oprah Winfrey, and more — whose dramatic shrinkdowns are turning heads and raising eyebrows across Hollywood.
Some slimmed-down celebs, like Oprah (pictured), are the same stars who have long championed curves, fuller figures, and body acceptance, making their transformations all the more shocking
Amy Schumer
Schumer, 44, stunned fans when she deleted her old Instagram photos and posted just a handful of recent snaps in a red mini dress that highlighted her long legs.
‘I’m feeling good and happy. Deleted my old pics for no reason!’ she wrote, signaling a fresh start.
Schumer has long been known for her honesty about her body, challenging Hollywood’s rigid beauty standards through comedy and film.
In Inside Amy Schumer and her 2018 movie I Feel Pretty, she refused retouching and openly joked about her curves, making her a body-positive role model for fans.
Beyond aesthetics, Schumer has shared her struggles with Cushing syndrome, which causes weight fluctuations, and perimenopause, both of which contributed to challenges in maintaining her ideal weight.
The comedian credits the GLP-1 drug Mounjaro for helping her lose roughly 40 pounds, though she previously tried Ozempic and had to stop due to severe side effects.
Amy Schumer, 44, stunned fans when she deleted her old Instagram photos and posted just a handful of recent snaps in a red mini dress that highlighted her long legs; (October 28, left, and in February 2024, right)
She’s also candid about the secretive Hollywood culture surrounding weight-loss medications.
‘Everyone’s like, “smaller portions.” Shut the f*** up. You’re on Ozempic or one of those things,’ she once said of the Hollywood slimdown.
Meghan Trainor
Trainor, 31, rose to fame as a curvy, body-positive singer with her 2014 hit All About That Bass, celebrating self-love and unapologetic confidence.
‘I ain’t no size two but I can shake it … I’m bringing booty back,’ she belted in the song that cemented her as a modern body-positivity icon.
Trainor, 31, rose to fame as a curvy, body-positive singer with her 2014 hit All About That Bass, celebrating self-love and unapologetic confidence; (left in August 2025, right in 2019)
Since the birth of her second child, Trainor has undergone a dramatic transformation.
In a March 2025 Instagram post, she revealed that GLP-1 drug Mounjaro was part of her journey, alongside working with a dietician, personal trainer, and major lifestyle changes.
‘I’ve been on a journey to be the healthiest, strongest version of myself for my kids and for me,’ she wrote, making it clear that her goal was wellness over pure aesthetics.
On her podcast Workin’ On It, Trainor explained that both friends and her doctor recommended the drug, reinforcing that even those known for body positivity are exploring medical options in the modern weight-loss era.
Rebel Wilson, 45, has been a beloved figure for decades, known for her role as Fat Amy in Pitch Perfect and her ability to blend humor with body-positive messaging.
In 2020, during her so-called ‘year of health,’ Wilson used Ozempic to help shed 80 pounds.
She combined the medication with high-intensity interval workouts, long hikes, and a high-protein, low-sugar diet.
After much speculation, Pitch Perfect star Rebel Wilson finally confessed to having used Ozempic to help her shed 80lbs during her ‘year of health’ back in 2020
Wilson has been transparent about regaining around 20 pounds due to stress, but she remains a vocal advocate for body acceptance.
‘Someone like me could have a bottomless appetite for sweets, so I think those drugs can be good,’ she told The Sunday Times.
Wilson’s transformation wasn’t just physical — it intersected with her career.
As someone who played characters often written around her former figure, she has discussed the pressure of losing roles tied to body type, while advocating for representation of diverse bodies in Hollywood.
She has also managed polycystic ovarian syndrome, which affects fertility and metabolism, making her openness about medical assistance especially impactful.
Reality star GG, 43, from Shahs of Sunset, lost significant weight after starting Ozempic in 2023, dropping from 138 pounds to 110 pounds.
GG approached her transformation deliberately, weighing herself only on injection days to track progress responsibly.
Reality star GG, 43, from Shahs of Sunset, lost significant weight after starting Ozempic in 2023, dropping from 138 pounds to 110 pounds
‘I decided I’m only gonna weigh myself on the days of my injections just to document it,’ she said, noting that she had gone slightly further than expected.
GG emphasized that rapid weight loss did not negatively impact her appearance.
‘Anytime anybody loses a lot of weight really fast, the skin just kinda droops down a little… as you can see, it did not affect my face.’
Known for her fiery personality on reality TV, GG encouraged fans struggling with weight loss to consider the drug thoughtfully, balancing results with overall wellness.
Oprah Winfrey
Winfrey, the media mogul and enduring icon of empowerment, revealed in 2023 that she used a GLP-1 drug to help lose nearly 50 pounds.
For decades, she struggled with yo-yo dieting and the constant cycle of guilt and restriction, something she calls ‘food noise’ — intrusive thoughts about eating that drive overeating.
In 2023, Oprah finally admitted to using an undisclosed GLP-1 — a type 2 diabetes medication that can also aid in weight loss — to shed nearly 50 pounds after decades of yo-yo dieting (Seen left in 2024 and right in 1992)
GLP-1 medications helped Oprah regain control over cravings and reduced compulsive eating, allowing her to approach weight management from a health-centered perspective.
‘I’m absolutely done with the shaming from other people and particularly myself,’ she said on The Oprah Podcast.
Kelly Clarkson
Clarkson, 43, has slimmed down with the aid of a prescription weight-loss drug, though she insists it is not Ozempic.
Clarkson, 43, has slimmed down with the aid of a prescription weight-loss drug, though she insists it is not Ozempic; (seen left this year and right in 2023)
The American Idol winner and Stronger singer has long been open about challenges with metabolism and thyroid issues, making her journey relatable to many fans.
Clarkson credits her doctor for guiding her safely and emphasizes that her transformation combines medical support with diet, exercise, and mental health care.
Clarkson’s career has always emphasized self-confidence and empowerment, from her music to her television presence.
Kathy Bates
Kathy Bates stunned fans at the 2025 Golden Globes with her slimmed-down figure.
The Matlock and Misery star lost roughly 80 pounds over several years through diet and exercise, then an additional 20 pounds with the help of Ozempic.
Actress Kathy Bates stunned attendees at the Golden Globes in January of this year with her slimmed-down figure (Seen left in February and right in 2015)
Diagnosed with type 2 diabetes in 2017, Bates has framed her weight loss as a health necessity rather than a purely aesthetic choice.
‘It’s very hard to say you’ve had enough,’ Bates once said, emphasizing the patience and effort required during her pandemic years.
Her story reflects both her commitment to personal health and her history of portraying strong, empowered female characters in Hollywood, from her Oscar-winning role in Misery to commanding performances in Titanic and Richard Jewell.
Whoopi Goldberg
Whoopi Goldberg, 67, known for her trailblazing career in comedy and television, turned to Mounjaro after reaching 300 pounds while filming Till in 2021.
She revealed the drug was a last resort after multiple failed attempts with other strategies, allowing her to regain control over her weight.
Whoopi previously revealed she used weight loss medication Mounjaro after hitting 300 Lbs (Seen left in February and right in 2019)
Whoopi Goldberg, 67, known for her trailblazing career in comedy and television, turned to Mounjaro after reaching 300 pounds while filming Till in 2021.
Goldberg has consistently emphasized authenticity and body acceptance, telling viewers: ‘Maybe that’s the key. Because, listen, when I realized how much I had put on… I always felt like me. And then I saw me and I thought, “Oh, that’s a lot of me.”’
Her journey illustrates how even the most iconic body-positive figures are navigating medical assistance to maintain health while honoring their identity.
Kelly Osbourne
Kelly Osbourne, 38, has lost 85 pounds postpartum, sparking rumors about her use of Ozempic — which she firmly denied. Instead, she attributes her weight loss to cutting sugar and carbohydrates, along with lifestyle changes.
Kelly has been open about her 85lb postpartum weight loss but has been clear she has not used Ozempic to help her shed the weight (Seen left in November and right in 2015)
‘I know everybody thinks I took Ozempic. I did not,’ she told People, emphasizing her transformation was achieved naturally.
Osbourne’s honesty highlights that while GLP-1s are a growing trend in Hollywood, she has long celebrated her curvy frame and body confidence, showing it’s possible to slim down without abandoning the body-positive values she’s defended for years.
